Cilia-Driven Leftward Flow Determines Laterality in Xenopus

  title={Cilia-Driven Leftward Flow Determines Laterality in Xenopus},
  author={Axel Schweickert and Thomas A. Weber and Tina Beyer and Philipp Vick and Susanne Bogusch and Kerstin Feistel and Martin Blum},
  journal={Current Biology},
Determination of the vertebrate left-right body axis during embryogenesis results in asymmetric development and placement of most inner organs. Although the asymmetric Nodal cascade is conserved in all vertebrates, the mechanism of symmetry breakage has remained controversial. In mammalian and fish embryos, a cilia-driven leftward flow of extracellular fluid is required for initiation of the Nodal cascade. This flow is localized at the posterior notochord ("node") and Kupffer's vesicle… CONTINUE READING
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