Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression

@article{Eisele2014CilengitideTO,
  title={Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression},
  author={Günter Eisele and Antje Wick and A. Eisele and Paul M J Clement and J{\"o}rg-Christian Tonn and Ghazaleh Tabatabai and Adrian F. Ochsenbein and Uwe Schlegel and Bart Neyns and Dietmar Krex and Matthias Simon and Guido Nikkhah and Martin Picard and Roger Stupp and Wolfgang Wick and Michael Weller},
  journal={Journal of Neuro-Oncology},
  year={2014},
  volume={117},
  pages={141-145}
}
The integrin antagonist cilengitide has been explored as an adjunct with anti-angiogenic properties to standard of care temozolomide chemoradiotherapy (TMZ/RT → TMZ) in newly diagnosed glioblastoma. Preclinical data as well as anecdotal clinical observations indicate that anti-angiogenic treatment may result in altered patterns of tumor progression. Using a standardized approach, we analyzed patterns of progression on MRI in 21 patients enrolled onto a phase 2 trial of cilengitide added to TMZ… 

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