Cilengitide targets pediatric glioma and neuroblastoma cells through cell detachment and anoikis induction

@article{Leblond2013CilengitideTP,
  title={Cilengitide targets pediatric glioma and neuroblastoma cells through cell detachment and anoikis induction},
  author={Pierre Leblond and Am{\'e}lie Dewitte and Florence le Tinier and Christine Bal-Mahieu and Marc Baroncini and Thierry Sarrazin and {\'E}ric Lartigau and Am{\'e}lie Lansiaux and Samuel Meignan},
  journal={Anti-Cancer Drugs},
  year={2013},
  volume={24},
  pages={818–825}
}
The prognosis of children with high-grade glioma or high-risk neuroblastoma remains poor. Cilengitide is a selective antagonist of &agr;v&bgr;3 and &agr;v&bgr;5 integrins, which are involved in tumor growth and development of metastasis. We have evaluated the effects of Cilengitide on pediatric glioma and neuroblastoma cell lines for the first time. Expression levels of &agr;v&bgr;3 and &agr;v&bgr;5 were determined by flow cytometry in three neuroblastoma and five pediatric glioma cell lines… Expand
Cilengitide Inhibits Attachment and Invasion of Malignant Pleural Mesothelioma Cells through Antagonism of Integrins αvβ3 and αvβ5
TLDR
Gene knockdown experiments indicated that the effects of cilengitide were, at least partly, due to antagonism of αvβ3 and αv β5 in MPM. Expand
Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a.
TLDR
Investigating whether modulation of attachment of neuroblastoma cells to extracellular matrix (ECM) proteins can affect their sensitivity to the 14G2a mAb treatment shows that the ECM proteins slightly modulate sensitivity of the cell lines to the mAb. Expand
Avβ3 integrin: Pathogenetic role in osteotropic tumors.
TLDR
The role of αvβ3 in malignant osteoclastogenesis and its potential targeting to restrain the bone colonization by skeleton invading cancers are reviewed. Expand
A Novel Small-Molecule Integrin Antagonist Inhibits Cells Adhesion Followed By Anoikis in Endothelial Cells - A Comparative Analysis with Cilengitide
TLDR
The purpose of the study was to examine the cellular effects and molecular mechanisms of a novel anti-integrin compound designated AV-398/38 and to compare it with cilengitide, one of the most advanced and best characterized αVβ3/αVβ5 integrin antagonists. Expand
Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma
TLDR
The impact of perifosine on proteome and lysine acetylome in SK-N-AS cells is detailed and the understanding of the mechanisms of perIFosine action in neuroblastoma is expanded. Expand
4D imaging and analysis of multicellular tumour spheroid cell migration and invasion
TLDR
This work developed a workflow for analysing complex 3D cell movement, taking into account migration within the spheroid as well as invasion into the surrounding matrix, which provided metrics characterising cell motion, which were used to evaluate the efficacy of chemother-apeutics on invasion. Expand
Vascular-homing peptides for targeted drug delivery and molecular imaging: meeting the clinical challenges.
TLDR
Recent findings in the clinical setting of vascular-homing peptides selected by in vivo phage display for the treatment of advanced malignancies and their altered vascular beds are given. Expand

References

SHOWING 1-10 OF 38 REFERENCES
Human Malignant Glioma Therapy Using Anti-αVβ3 Integrin Agents
TLDR
It is indicated that cRGDfV induced apoptosis of human glioma cells by binding αVβ3 integrin expressed on their cell surfaces and that cGly-Asp-D-Phe-Val may be an effective and non-toxic direct anti-tumor therapy for αV β3-expressing GBMs. Expand
Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule‐dependency
TLDR
It is found that a single dose of cilengitide given between 4 and 12 hr prior to radiation was sufficient to produce the same effect, and suggests possible clinical translation for glioma therapy. Expand
Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents.
TLDR
It is indicated that cRGDfV induced apoptosis of human glioma cells by binding alpha(v)beta3 integrin expressed on their cell surfaces and that cGlyAspD-Phe-Val may be an effective and non-toxic direct anti-tumor therapy for alpha( v) beta3-expressing GBMs. Expand
Preferential Susceptibility of Brain Tumors to the Antiangiogenic Effects of an &agr;v Integrin Antagonist
TLDR
The cyclic pentapeptide EMD 121974 may become a treatment option specific to brain tumors because of its antiangiogenic effect, and its use may be especially indicated after tumors are removed surgically. Expand
Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro.
TLDR
It is found that, at clinically relevant concentrations, cilengitide induces detachment in some but not all glioma cell lines, while the effect on cell viability is modest, and suggests that the beneficial clinical effects derived from cilENGitide in vivo may arise from altered perfusion, which promotes temozolomide delivery toglioma cells. Expand
Integrin αvβ3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non–small-cell lung cancer models
TLDR
It is concluded that radiation induces expression of α v β 3 integrin in endothelial and non–small-cell lung cancer models, and that integrin antagonist Cilengitide is a radiosensitizer in proportion to the levels of target integrin expression. Expand
Combination therapy of cilengitide with belotecan against experimental glioblastoma
TLDR
In vitro and in vivo the antitumor effects of combination therapy of cilengitide with belotecan, a camptothecin derivate, to treat experimental glioblastoma presented more cytotoxic effects compared to the monotherapy of either drug in vitro andIn vivo. Expand
Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway
TLDR
Cilengitide inhibits integrin-dependent signaling, causes disassembly of cytoskeleton, cellular detachment and induction of apoptosis in endothelial and glioma cells thereby explaining the profound activity of integrin inhibitors in gliomas. Expand
EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE
TLDR
This standardized brain tumor model is highly reproducible and useful for testing new treatment regimens, and Cilengitide is highly effective in suppressing blood vessel growth, thereby controlling orthotopic growth of this glioblastoma cell line. Expand
Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models.
TLDR
It is concluded that radiation induces expression of alpha v beta 3 integrin in endothelial and non-small-cell lung cancer models, and that integrin antagonist Cilengitide is a radiosensitizer in proportion to the levels of target integrin expression. Expand
...
1
2
3
4
...