Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

@inproceedings{Nicholson2006CiguatoxinsCP,
  title={Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function},
  author={Graham M. Nicholson and Richard James Lewis},
  year={2006}
}
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders. The pharmacology of ciguatoxins is characterised by their ability to cause persistent activation of voltage-gated sodium channels, to increase neuronal excitability and… CONTINUE READING

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