Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

@article{Shaykhiev2010CigaretteSR,
  title={Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo},
  author={Renat R. Shaykhiev and Fouad Otaki and Prince Osei Bonsu and David T. Dang and Matthew R Teater and Yael Strulovici-Barel and Jacqueline Salit and B P Harvey and Ronald G. Crystal},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={877-892}
}
The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are associated with increased lung epithelial permeability, we hypothesized that smoking alters the transcriptional program regulating airway epithelial AJC integrity. Transcriptome analysis revealed global down-regulation of physiological AJC gene expression in the… CONTINUE READING