Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans.

@article{Gadek1979CigaretteSI,
  title={Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans.},
  author={James E. Gadek and Gerald A. Fells and Ronald G. Crystal},
  journal={Science},
  year={1979},
  volume={206 4424},
  pages={1315-6}
}
Current concepts of the pathogenesis of emphysema suggest that it results from an imbalance of elastase and antielastase activity within the alveolar structures. Although emphysema that is associated with hereditary deficiency of serum alpha 1-antitrypsin conforms to this scheme, the major risk factor in the more common form of emphysema is cigarette smoking. A study was designed to evaluate the premise that cigarette smoking may be associated with an acquired, functional defect in lung alpha 1… CONTINUE READING