Cigarette smoking and aneuploidy in human sperm

  title={Cigarette smoking and aneuploidy in human sperm},
  author={Qinghua Shi and Evelyn Ko and Leona Barclay and Tina Hoang and Alfred Rademaker and Ren{\'e}e H. Martin},
  journal={Molecular Reproduction and Development},
Cigarette smoke contains chemicals which are capable of inducing aneuploidy in experimental systems. These chemicals have been shown to reach the male reproductive system, increasing oxidative DNA damage in human sperm and lowering semen quality. We have examined the association between smoking and aneuploid sperm by studying 31 Chinese men with similar demographic characteristics and lifestyle factors except for cigarette smoking. None of the men drank alcohol. These men were divided into… 

Genetic abnormality of sperm in smoker

It is indicated that smoking cigarette causes numerical of sex chromosome aberration in sperm.

Effect of lifestyle exposures on sperm aneuploidy

A new analysis is presented that summarizes published studies of smoking effects on sperm chromosome number and demonstrates a statistically significant increase in sperm disomy among smokers compared to nonsmokers (P < 0.001).

Lifestyle factors and sperm aneuploidy.

The mutagenic effect of tobacco smoke on male fertility

Evidence that smoking has a mutagenic effect on sperm and how this subsequently affects male fertility is provided and the role of tobacco smoke as an aneugen will be explored.

Smoking-induced chromosomal segregation anomalies identified by FISH analysis of sperm

The results suggest that errors can occur in both meiosis I and II, confirming the emerging literature that the male meiotic process may generally be affected by the genotoxic damage from tobacco use.

The effects of male age on sperm DNA damage in healthy non-smokers.

Investigation of the associations between male age and sperm DNA damage and the influence of several lifestyle factors in a healthy non-clinical group of 80 non-smokers with no known fertility problems indicates that older men have increased sperm DNADamage associated with alkali-labile sites or single-strand DNA breaks and independent of age, men with substantial daily caffeine consumption have increased DNA damage associated with double-stranded DNA breaks.

The relationship between exposure to air pollution and sperm disomy

Exposure to air pollution induces sperm aneuploidy, according to the hypothesis that exposure to specific air pollutants increases sperm disomy.



Smoking cigarettes is associated with increased sperm disomy in teenage men.

Smoking and male reproduction: a review.

  • M. Vine
  • Medicine
    International journal of andrology
  • 1996
It is concluded that, although smokers as a group may not experience reduced fertility, men with marginal semen quality who wish to have children may benefit from quitting smoking, since several small studies indicate the potential for improved semen quality after quitting smoking.

Aneuploidy in sperm and exposure to fungicides and lifestyle factors

The present study supports earlier ones showing that smoking can increase aneuploidy in human sperm and suggests that the sensitivity of the sperm‐FISH method may not be sufficient for low‐level exposures.

Sperm chromatin damage associated with male smoking.

Use of fluorescence in situ hybridization (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men

Sperm FISH proved to be a useful biomarker to detect and compare numerical cytogenetic abnormalities in human sperm cells across differing levels of exposure to smoking, caffeine, and alcohol.

Spontaneous frequencies of aneuploid and diploid sperm in 10 normal Chinese men: assessed by multicolor fluorescence in situ hybridization

The data reported here show no marked differences in disomy and diploidy frequencies between the mainland Chinese and Canadian groups, if donor heterogeneity is taken into account.

Smoking and reproduction: gene damage to human gametes and embryos.

  • M. Zenzes
  • Biology
    Human reproduction update
  • 2000
Assisted conception is a useful methodology for detecting disturbances in clinical outcome, meiotic maturation, and genetic integrity of human gametes, and smoking-related adducts were detectable in ovarian granulosa-lutein cells, oocytes, spermatozoa and preimplantation embryos.

Abnormalities for chromosomes 13 and 21 detected in spermatozoa from infertile men.

It is suggested that infertile men, who are prime candidates for intracytoplasmic sperm injection, may be at a very small increased risk of aneuploid offspring.

Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.

The results corroborate the pooled data obtained from human sperm karyotypes and suggest that the sex chromosome bivalent and the chromosome 21 bivalent are more susceptible to nondisjunction during spermatogenesis.

Donor age and the frequency of disomy for chromosomes 1, 13, 21 and structural abnormalities in human spermatozoa using multicolour fluorescence in-situ hybridization.

A statistically significant association with donor age was detected for the frequency of acentric fragments of chromosome 1 (P < 0.05) and the Pearson correlation coefficients were calculated to determine if a relationship existed between donor age and the frequencyof chromosome abnormalities in spermatozoa.