Cigarette smoking and aneuploidy in human sperm

@article{Shi2001CigaretteSA,
  title={Cigarette smoking and aneuploidy in human sperm},
  author={Qinghua Shi and Evelyn Ko and Leona Barclay and Tina Hoang and Alfred W. Rademaker and R. H. Mart{\'i}n},
  journal={Molecular Reproduction and Development},
  year={2001},
  volume={59}
}
  • Q. Shi, E. Ko, +3 authors R. Martín
  • Published 1 August 2001
  • Biology, Medicine
  • Molecular Reproduction and Development
Cigarette smoke contains chemicals which are capable of inducing aneuploidy in experimental systems. These chemicals have been shown to reach the male reproductive system, increasing oxidative DNA damage in human sperm and lowering semen quality. We have examined the association between smoking and aneuploid sperm by studying 31 Chinese men with similar demographic characteristics and lifestyle factors except for cigarette smoking. None of the men drank alcohol. These men were divided into… 
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A new analysis is presented that summarizes published studies of smoking effects on sperm chromosome number and demonstrates a statistically significant increase in sperm disomy among smokers compared to nonsmokers (P < 0.001).
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It is demonstrated that changing the men's lifestyle habits may contribute to reduction of the incidence of sperm aneuploidy, and it is necessary that men continue to follow sensible health advice concerning excess weight, coffee drinking and wearing tight fitting underwear.
The mutagenic effect of tobacco smoke on male fertility
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Evidence that smoking has a mutagenic effect on sperm and how this subsequently affects male fertility is provided and the role of tobacco smoke as an aneugen will be explored.
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TLDR
It is shown that MS and SS smoke have differential effects on the genetic integrity and function of sperm and provide further evidence that male exposure to second-hand smoke, as well as direct cigarette smoke, may diminish a couple's chance for a successful pregnancy and the birth of a healthy baby.
Smoking-induced chromosomal segregation anomalies identified by FISH analysis of sperm
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The results suggest that errors can occur in both meiosis I and II, confirming the emerging literature that the male meiotic process may generally be affected by the genotoxic damage from tobacco use.
The effects of male age on sperm DNA damage in healthy non-smokers.
TLDR
Investigation of the associations between male age and sperm DNA damage and the influence of several lifestyle factors in a healthy non-clinical group of 80 non-smokers with no known fertility problems indicates that older men have increased sperm DNADamage associated with alkali-labile sites or single-strand DNA breaks and independent of age, men with substantial daily caffeine consumption have increased DNA damage associated with double-stranded DNA breaks.
Cigarette smoking and male infertility
TLDR
It is concluded that although some smokers may not experience reduced fertility, men with marginal semen quality can benefit from quitting smoking.
Cigarette smoking affects specific sperm oxidative defenses but does not cause oxidative DNA damage in infertile men.
TLDR
It is demonstrated that smoking has a negative impact on intracellular antioxidant enzymes but that effect does not increase oxidative DNA damage.
The relationship between exposure to air pollution and sperm disomy
TLDR
Exposure to air pollution induces sperm aneuploidy, according to the hypothesis that exposure to specific air pollutants increases sperm disomy.
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