Cigarette smoking and aneuploidy in human sperm

@article{Shi2001CigaretteSA,
  title={Cigarette smoking and aneuploidy in human sperm},
  author={Qinghua Shi and Evelyn Ko and Leona Barclay and Tina Hoang and Alfred Rademaker and Ren{\'e}e H. Martin},
  journal={Molecular Reproduction and Development},
  year={2001},
  volume={59}
}
Cigarette smoke contains chemicals which are capable of inducing aneuploidy in experimental systems. These chemicals have been shown to reach the male reproductive system, increasing oxidative DNA damage in human sperm and lowering semen quality. We have examined the association between smoking and aneuploid sperm by studying 31 Chinese men with similar demographic characteristics and lifestyle factors except for cigarette smoking. None of the men drank alcohol. These men were divided into… 

Genetic abnormality of sperm in smoker

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A new analysis is presented that summarizes published studies of smoking effects on sperm chromosome number and demonstrates a statistically significant increase in sperm disomy among smokers compared to nonsmokers (P < 0.001).

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Evidence that smoking has a mutagenic effect on sperm and how this subsequently affects male fertility is provided and the role of tobacco smoke as an aneugen will be explored.

Smoking-induced chromosomal segregation anomalies identified by FISH analysis of sperm

The results suggest that errors can occur in both meiosis I and II, confirming the emerging literature that the male meiotic process may generally be affected by the genotoxic damage from tobacco use.

The effects of male age on sperm DNA damage in healthy non-smokers.

Investigation of the associations between male age and sperm DNA damage and the influence of several lifestyle factors in a healthy non-clinical group of 80 non-smokers with no known fertility problems indicates that older men have increased sperm DNADamage associated with alkali-labile sites or single-strand DNA breaks and independent of age, men with substantial daily caffeine consumption have increased DNA damage associated with double-stranded DNA breaks.

The relationship between exposure to air pollution and sperm disomy

Exposure to air pollution induces sperm aneuploidy, according to the hypothesis that exposure to specific air pollutants increases sperm disomy.
...

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