Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.

@article{Wickenden2003CigaretteSP,
  title={Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis.},
  author={Julie A Wickenden and Murray C. H. Clarke and Adriano G Rossi and Irfan Rahman and Stephen P. Faux and Ken Donaldson and W. MacNee},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={29 5},
  pages={562-70}
}
Emphysema is characterized by enlargement of the distal airspaces in the lungs due to destruction of alveolar walls. Alveolar endothelial and epithelial cell apoptosis induced by cigarette smoke is thought to be a possible mechanism for this cell loss. In contrast, our studies show that cigarette smoke condensate (CSC) induces necrosis in alveolar epithelial cells and human umbilical vein endothelial cells. Furthermore, study of the cell death pathway in a model system using Jurkat cells… CONTINUE READING
56 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…