Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.

@article{Salem2013CigaretteSM,
  title={Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.},
  author={Ahmed F. Salem and Mazhar Al-Zoubi and Diana Whitaker-Menezes and Ubaldo e. Martinez-outschoorn and Rebecca Lamb and James Hulit and Anthony Howell and Ricardo Gandara and Marina Sartini and Ferruccio Galbiati and Generoso Bevilacqua and Federica Sotgia and Michael Phillip Lisanti},
  journal={Cell cycle},
  year={2013},
  volume={12 5},
  pages={818-25}
}
Cigarette smoke has been directly implicated in the disease pathogenesis of a plethora of different human cancer subtypes, including breast cancers. The prevailing view is that cigarette smoke acts as a mutagen and DNA damaging agent in normal epithelial cells, driving tumor initiation. However, its potential negative metabolic effects on the normal stromal microenvironment have been largely ignored. Here, we propose a new mechanism by which carcinogen-rich cigarette smoke may promote cancer… CONTINUE READING