Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

@article{Yang2006CigaretteSI,
  title={Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.},
  author={S R Eric Yang and Asiya Seema Chida and Mark R Bauter and Nusrat Shafiq and Kathryn E. Seweryniak and Sanjay B. Maggirwar and Iain C. Kilty and Irfan Rahman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 1},
  pages={L46-57}
}
Cigarette smoke-mediated oxidative stress induces an inflammatory response in the lungs by stimulating the release of proinflammatory cytokines. Chromatin remodeling due to histone acetylation and deacetylation is known to play an important role in transcriptional regulation of proinflammatory genes. The aim of this study was to investigate the molecular mechanism(s) of inflammatory responses caused by cigarette smoke extract (CSE) in the human macrophage-like cell line MonoMac6 and whether the… CONTINUE READING
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