Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes.

@article{Menon2011CigaretteSI,
  title={Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes.},
  author={Ramkumar Menon and Stephen J. Fortunato and J Yu and Ginger L Milne and Sara Serafina S{\'a}nchez and Cayce Owens Drobek and Martha Lappas and Robert K N Taylor},
  journal={Placenta},
  year={2011},
  volume={32 4},
  pages={317-22}
}
Cigarette smoking and bacterial infections are two major risk factors associated with preterm prelabor rupture of membranes (pPROM). We hypothesized that exposure of fetal membranes to cigarette smoke extracts might induce oxidative stress (OS) and fetal membrane apoptosis, culminating in an alternate pathway to that commonly activated by infection. To test this, we characterized the production of prostanoids and biomarkers of apoptosis in normal term human fetal membrane explant cultures… CONTINUE READING
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