Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
@article{Martey2004CigaretteSI, title={Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.}, author={Christine A Martey and Stephen J. Pollock and Chantal K Turner and Katherine O'Reilly and Carolyn J. Baglole and Richard P. Phipps and Patricia J. Sime}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2004}, volume={287 5}, pages={ L981-91 } }
Cigarette smoking can lead to many human pathologies including cardiovascular and respiratory disease. Recent studies have defined a role for fibroblasts in the development of colon cancer. Moreover, fibroblasts are now thought of as key "sentinel" cells that initiate inflammation by releasing proinflammatory mediators including prostaglandins (PGs). Pathological overexpression of cyclooxygenase-2 (COX-2) and excess eicosanoid production are found in the early stages of carcinogenesis. By…
202 Citations
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The most recent advances in the understanding of mPGES-1 in airway inflammation, COPD, allergic airway diseases, respiratory response to hypoxia, and lung cancers are covered.
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- 2006
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