Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways.

@article{Kroening2008CigaretteSO,
  title={Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways.},
  author={Paula R. Kroening and Terrance W. Barnes and Larry Pease and Andrew H. Limper and Hirohito Kita and Robert Vassallo},
  journal={Journal of immunology},
  year={2008},
  volume={181 2},
  pages={1536-47}
}
IL-12p70, a heterodimer composed of p35 and p40 subunits, is a key polarizing cytokine produced by maturing dendritic cells (DCs). We report that cigarette smoke extract (CSE), an extract of soluble cigarette smoke components, suppresses both p35 and p40 production by LPS or CD40L-matured DCs. Suppression of IL-12p70 production from maturing DCs was not observed in the presence of nicotine concentrations achievable in CSE or in the circulation of smokers. The suppressed IL-12p70 protein… CONTINUE READING
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