Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.

@article{Reynolds2006CigaretteSE,
  title={Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.},
  author={Paul R Reynolds and Manuel G. Cosio and John R. Hoidal},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={35 3},
  pages={314-9}
}
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is a progressive and irreversible disorder. Cigarette smoking is associated with 80-90% of COPD cases; however, the genes involved in COPD-associated emphysema and chronic inflammation are poorly understood. It was recently demonstrated that early growth response gene 1 (Egr-1) is significantly upregulated in the lungs of smokers with COPD (Ning W and coworkers, Proc Natl Acad Sci 2004;101:14895… CONTINUE READING