Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation.

@article{Nakamura2008CigaretteSE,
  title={Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation.},
  author={Yuki Nakamura and Masanori Miyata and Tetsuro Ohba and Takashi Ando and Kyosuke Hatsushika and Fumiko Suenaga and Naomi Shimokawa and Yuko Ohnuma and R. Katoh and Hideoki Ogawa and Atsuhito Nakao},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={122 6},
  pages={1208-14}
}
BACKGROUND Both active and passive smoking are considered to be risk factors for asthma development. However, the precise mechanisms involved remain elusive. Recently, thymic stromal lymphopoietin (TSLP) has been shown to play a key role in the development of T(H)2-type allergic inflammation in patients with asthma. OBJECTIVE The aim of this study was to investigate whether there was a causal relationship between cigarette smoke exposure and TSLP expression in the lung. METHODS We examined… CONTINUE READING
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The role of environmental tobacco smoke in the origins and progression of asthma

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