Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells.

@article{Deen2007CigaretteSE,
  title={Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells.},
  author={Margaretha van der Deen and Elisabeth G. E. de Vries and Hylke Visserman and Wouter Zandbergen and Dirkje S Postma and Wim Timens and Hetty Timmer-Bosscha},
  journal={Journal of biochemical and molecular toxicology},
  year={2007},
  volume={21 5},
  pages={243-51}
}
Cigarette smoke is the principal risk factor for development of chronic obstructive pulmonary disease (COPD). Multidrug resistance-associated protein 1 (MRP1) is a member of the ATP-binding cassette (ABC) superfamily of transporters, which transport physiologic and toxic substrates across cell membranes. MRP1 is highly expressed in lung epithelium. This study aims to analyze the effect of cigarette smoke extract (CSE) on MRP1 activity. In the human bronchial epithelial cell line 16HBE14o-, MRP1… CONTINUE READING

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