Cigarette smoke exposure facilitates allergic sensitization in mice

  title={Cigarette smoke exposure facilitates allergic sensitization in mice},
  author={Katrien B. Moerloose and Lander J. Robays and Tania Maes and Guy G Brusselle and Kurt G. Tournoy and Guy F Joos},
  journal={Respiratory Research},
  pages={49 - 49}
BACKGROUND Active and passive smoking are considered as risk factors for asthma development. The mechanisms involved are currently unexplained. OBJECTIVE The aim of this study was to determine if cigarette smoke exposure could facilitate primary allergic sensitization. METHODS BALB/c mice were exposed to aerosolized ovalbumin (OVA) combined with air or tobacco smoke (4 exposures/day) daily for three weeks. Serology, lung cytopathology, cytokine profiles in bronchoalveolar lavage fluid (BALF… CONTINUE READING