Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages.

  title={Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages.},
  author={Gordon J. Gaschler and Caleb C. J. Zavitz and Carla M. T. Bauer and Marko {\vS}krti{\'c} and Maria Lindahl and Clinton S. Robbins and Biao Chen and Martin R. St{\"a}mpfli},
  journal={American journal of respiratory cell and molecular biology},
  volume={38 2},
Alveolar macrophages (aMs) play a central role in respiratory host defense by sensing microbial antigens and initiating immune-inflammatory responses early in the course of an infection. The purpose of this study was to investigate the effect of cigarette smoke exposure on aMs after stimulation of innate pattern recognition receptors (PRRs) in a murine model. To accomplish this, C57BL/6 mice were exposed for 8 weeks using two models of cigarette smoke exposure, nose-only or whole-body exposure… CONTINUE READING
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