Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

@article{Hardison2012CigaretteSE,
  title={Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.},
  author={Matthew Thomas Hardison and Michael D Brown and Robert J Snelgrove and J Edwin Blalock and Patricia Jackson},
  journal={Frontiers in bioscience},
  year={2012},
  volume={4},
  pages={2402-9}
}
Several chronic lung diseases have been linked to cigarette smoking (Chronic Obstructive Pulmonary Disease (COPD), and cancer are associated with increased tobacco use). We recently described a collagen fragment, proline-glycine-proline (PGP), chemotactic for neutrophils, that appears to play a role in COPD, cystic fibrosis, and bronchiolitis obliterans syndrome. PGP can exist in either its native or acetylated form (NAcPGP), although the mechanism of N-terminal-acetylation remains unknown… CONTINUE READING
Highly Cited
This paper has 219 citations. REVIEW CITATIONS