Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

  title={Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.},
  author={Matthew Thomas Hardison and Michael D Brown and Robert J Snelgrove and J Edwin Blalock and Patricia Jackson},
  journal={Frontiers in bioscience},
Several chronic lung diseases have been linked to cigarette smoking (Chronic Obstructive Pulmonary Disease (COPD), and cancer are associated with increased tobacco use). We recently described a collagen fragment, proline-glycine-proline (PGP), chemotactic for neutrophils, that appears to play a role in COPD, cystic fibrosis, and bronchiolitis obliterans syndrome. PGP can exist in either its native or acetylated form (NAcPGP), although the mechanism of N-terminal-acetylation remains unknown… CONTINUE READING
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