Cigarette smoke condensate activates nuclear transcription factor-κ B through phosphorylation and degradation of I κ B α : correlation with induction of cyclooxygenase-2

@inproceedings{Anto2002CigaretteSC,
  title={Cigarette smoke condensate activates nuclear transcription factor-κ B through phosphorylation and degradation of I κ B α : correlation with induction of cyclooxygenase-2},
  author={Ruby John Anto and Asok Mukhopadhyay and Shishir Shishodia and C. Gary Gairola and Bharat Bhushan Aggarwal},
  year={2002}
}
Cigarette smoke (CS) contains several carcinogens known to initiate and promote tumorigenesis and metastasis. Because various genes that mediate carcinogenesis and tumorigenesis are regulated by nuclear factor-κB (NF-κB), we postulated that the effects of CS must be mediated through activation of this transcription factor. Therefore, in the present report we investigated whether cigarette smoke condensate (CSC) activates NF-κB, and whether the pathway employed for activation is similar to that… CONTINUE READING

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