Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

@article{Marwick2004CigaretteSA,
  title={Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.},
  author={John A. Marwick and Paul A. Kirkham and Christopher S. Stevenson and Henry Danahay and June Giddings and Keith Butler and Ken Donaldson and W. MacNee and Irfan Rahman},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 6},
  pages={633-42}
}
Cigarette smoke-triggered inflammation is considered to play a central role in the development of chronic obstructive pulmonary disease by a mechanism that may involve enhanced proinflammatory gene transcription. Histone acetylation and deacetylation is a key regulator of the specificity and duration of gene transcription. Disruption in the nuclear histone acetylation:deacetylation balance (chromatin remodeling) may result in excessive transcription of specific proinflammatory genes in the… CONTINUE READING