Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

@article{Marwick2004CigaretteSA,
  title={Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.},
  author={J. Marwick and P. Kirkham and C. Stevenson and H. Danahay and J. Giddings and K. Butler and K. Donaldson and W. MacNee and I. Rahman},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 6},
  pages={
          633-42
        }
}
  • J. Marwick, P. Kirkham, +6 authors I. Rahman
  • Published 2004
  • Medicine, Biology
  • American journal of respiratory cell and molecular biology
  • Cigarette smoke-triggered inflammation is considered to play a central role in the development of chronic obstructive pulmonary disease by a mechanism that may involve enhanced proinflammatory gene transcription. Histone acetylation and deacetylation is a key regulator of the specificity and duration of gene transcription. Disruption in the nuclear histone acetylation:deacetylation balance (chromatin remodeling) may result in excessive transcription of specific proinflammatory genes in the… CONTINUE READING
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