Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture

  title={Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture},
  author={Nohra Chalouhi and Muhammad S. Ali and Robert M Starke and P Jabbour and S Tjoumakaris and L. Fernando Gonzalez and R H Rosenwasser and Walter J Koch and Aaron Sean Dumont},
  booktitle={Mediators of inflammation},
Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen… CONTINUE READING
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Cigarette smoke directly produces a pro-inflammatory/matrix remodeling phenotype in cerebral vascular smooth muscle cells via KLF4: a potential mechanism for cerebral aneurysm pathogenesis

  • M. Ali, Z. Yu, P. Jabbour
  • Stroke, vol. 43, Article ID A112, 2012.
  • 2012
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