Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

@article{Starke2018CigaretteSI,
  title={Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.},
  author={Robert M Starke and John W Thompson and Muhammad S. Ali and Crissey L. Pascale and Alejandra Martinez Lege and Dale Ding and Nohra Chalouhi and David M Hasan and P Jabbour and Gary K. Owens and Michal Toborek and Joshua M Hare and Aaron Sean Dumont},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2018},
  volume={38 3},
  pages={610-621}
}
OBJECTIVE Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on vascular smooth muscle cell (VSMC) phenotypic modulation and pathogenesis of CAs is unknown. The goal of this study was to investigate whether CSE activates a NOX (NADPH oxidase)-dependent pathway leading to VSMC phenotypic modulation and CA… CONTINUE READING
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