Cigarette Smoke Increases Gastric Ulcer Size in Part by an Angiotensin II-Mediated Mechanism in Rats

To assess the mechanism of the effect ofcigarette smoke on ulcer disease we employed a rat modelin which cigarette smoke increases the size of aceticacid-induced gastric ulcer and decreases the hyperemia at the ulcer margin. We postulate thatcigarette smoke increases angiotensin II (avasoconstrictor) in ulcer tissue. Since directmeasurement of angiotensin… CONTINUE READING