Ciclindole and flucindole: Novel tetrahydrocarbazolamine neuroleptics

  title={Ciclindole and flucindole: Novel tetrahydrocarbazolamine neuroleptics},
  author={Paul L. Wood and Paul S. Mcquade},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • P. WoodP. Mcquade
  • Published 31 December 1984
  • Biology, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
4 Citations

Modulation of In Vivo Dopamine Release by D2 but Not D1 Receptor Agonists and Antagonists

The in vivo release of DA from mesolimbic and neostriatal DA neurons appears to be modulated by D2 but not by D1 receptors, whereas both receptor types can modulate DA metabolism.

In Vivo Assessment of Dopamine and Norepinephrine Release in Rat Neocortex: Gas Chromatography‐Mass Spectrometry Measurement of 3‐Methoxytyramine and Normetanephrine

Data indicate that this new assay is a useful approach for the in vivo evaluation of DA and NE release in cortical regions of the rat, and is unique in that no surgery, restraint, or anesthetic is required, thereby permitting more complicated experimental paradigms to be utilized.

The catalytic asymmetric Fischer indolization.

The first catalytic asymmetric Fischer indolization is reported, in the presence of a 5 mol % loading of a novel spirocyclic chiral phosphoric acid, which gives various 3-substituted tetrahydrocarbazoles in generally high yields.



Differential actions of classical and atypical neuroleptics on mouse nigrostriatal neurons

Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology.

The strict structural requirements for binding to this site substantiate its unique character and suggest that it may represent a tryptamine receptor in the CNS.

Mapping the dopamine receptor. 1. Features derived from modifications in ring E of the neuroleptic butaclamol.

The existence of a previously proposed lipophilic accessory binding site on the receptor macromolecule has been confirmed and its minimum dimensions and locus with respect to the primary binding sites have been defined.

Actions of GABAergic agents on dopamine metabolism in the nigrostriatal pathway of the rat.

  • P. Wood
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1982
Multiple GABA receptors appear to be present within the central nervous system which possess differential sensitivities to the GABA agonists examined; however, after parenteral administration, all GABAergics appear to depress nigrostriatal dopaminergic transmission.

Absorption, excretion and disposition of cyclindole in laboratory animals and human volunteers.

Radioactivity from orally administered single doses of cyclindole-14C was excreted primarily in the urine of the rat, monkey, and dog, and substantial amounts of unchanged drug were voided by dogs.

A selected ion monitoring assay for dopamine and its metabolites using negative chemical ionization.

  • P. Wood
  • Chemistry
    Biomedical mass spectrometry
  • 1982
A comparison of electron impact, positivechemical ionization and negative chemical ionization conditions indicated dramatic increases in sensitivity with negative chemical Ionization.