Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells.

@article{Zhu2015CichoricAR,
  title={Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells.},
  author={Di Zhu and Yutang Wang and Qingwei Du and Zhigang Liu and Xuebo Liu},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 51},
  pages={
          10903-13
        }
}
  • Di Zhu, Yutang Wang, +2 authors X. Liu
  • Published 17 December 2015
  • Biology, Medicine
  • Journal of agricultural and food chemistry
Cichoric acid, a caffeic acid derivative found in Echinacea purpurea, basil, and chicory, has been reported to have bioactive effects, such as anti-inflammatory, antioxidant, and preventing insulin resistance. In this study, to explore the effects of CA on regulating insulin resistance and chronic inflammatory responses, the insulin resistance model was constructed by glucosamine in HepG2 cells. CA stimulated glucosamine-mediated glucose uptake by stimulating translocation of the glucose… Expand
Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury
Cichoric acid (CA), a plant-based nutraceutical, is extracted from Echinacea purpurea and other edible plants and vegetables and exhibits multiple biological functions, including antioxidant andExpand
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Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells.
TLDR
It is demonstrated that CA has a Bmal1 resistance to lipid accumulation by enhancing the Akt/GSK3β signaling pathways and modulating the downstream expressions related to lipid metabolism, which indicated that CA might be useful as a natural and promising nonalcoholic fatty liver diseases (NAFLD) modulator. Expand
Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice.
  • Di Zhu, Xinglin Zhang, +5 authors X. Liu
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2017
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CA inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion and regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses, which contributes to the improvement in athletic ability and diabetic myopathy. Expand
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