Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

@article{Jger2001Cic1AA,
  title={Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.},
  author={Szilvia J{\"a}ger and Jochen Strayle and Wolfgang Heinemeyer and Dieter H. Wolf},
  journal={The EMBO journal},
  year={2001},
  volume={20 16},
  pages={4423-31}
}
In eukaryotes, the ubiquitin-proteasome system plays a major role in selective protein breakdown for cellular regulation. Here we report the discovery of a new essential component of this degradation machinery. We found the Saccharomyces cerevisiae protein Cic1 attached to 26S proteasomes playing a crucial role in substrate specificity for proteasomal destruction. Whereas degradation of short-lived test proteins is not affected, cic1 mutants stabilize the F-box proteins Cdc4 and Grr1, substrate… CONTINUE READING

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