Chymotrypsin-specific protease inhibitors decrease H2O2 formation by activated human polymorphonuclear leukocytes.

@article{Frenkel1987ChymotrypsinspecificPI,
  title={Chymotrypsin-specific protease inhibitors decrease H2O2 formation by activated human polymorphonuclear leukocytes.},
  author={Krystyna Frenkel and Keith Chrzan and Clarence A. Ryan and Rainer Wiesner and Walter Troll},
  journal={Carcinogenesis},
  year={1987},
  volume={8 9},
  pages={1207-12}
}
Stimulated phagocytic cells generate active oxygen species which are known to contribute to inflammatory diseases, necrosis of surrounding tissues, mutagenicity and carcinogenicity. Until now, it was not certain whether protease inhibitors are capable of decreasing the production of those oxygen species, and if they are, what type of protease inhibitor is the most active. In this work we monitored formation of H2O2 by 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated polymorphonuclear… CONTINUE READING
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