Chymotrypsin, ileal chloride transport, and neurotransmitters.

  • Kerry A Hubel
  • Published 1984 in The American journal of physiology


Electrical field stimulation (EFS) depolarizes nerves and causes chloride secretion by mucosa of rabbit ileum mounted in a flux chamber. To test the hypothesis that the transmitter is a peptide, we determined whether the EFS response was prevented by the endopeptidase chymotrypsin (CT). Serosal, but not mucosal, addition of CT (200 micrograms/ml) reduced… (More)