Chymopapain, chemonucleolysis, and nucleus pulposus regeneration. A biochemical and biomechanical study.

@article{Bradford1984ChymopapainCA,
  title={Chymopapain, chemonucleolysis, and nucleus pulposus regeneration. A biochemical and biomechanical study.},
  author={David S. Bradford and Theodore R. Oegema and Kay M. Cooper and Koichi Wakano and Edmund Y. S. Chao},
  journal={Spine},
  year={1984},
  volume={9 2},
  pages={
          135-47
        }
}
In the adult mongrel dog, in vivo injection of chymopapain into the intervertebral disc resulted, at two weeks, in disc space narrowing. However, [35S]sulfate labeling and proteoglycan characterization demonstrate that the nucleus retains the ability to synthesize proteoglycans, although they were degraded rapidly by residual proteolytic activity. Three months following chymopapain treatment, the intervertebral dog disc shows that an increase in disc height, return of nuclear material, and… CONTINUE READING

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