Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension.

@article{Shiota1997ChymaseIA,
  title={Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension.},
  author={Naotaka Shiota and Denan Jin and Shinji Takai and Tetsuya Kawamura and Masamichi Koyama and Norihiro Nakamura and Mizuo Miyazaki},
  journal={FEBS letters},
  year={1997},
  volume={406 3},
  pages={301-4}
}
Chronic pressure overload induces cardiac tissue remodeling. Chymase is known to regulate matrix metabolism and angiotensin II formation. In the present study, we investigated the pathophysiological functions of chymase in the pressure-overloaded hamster heart induced by a two-kidney, one-clip (2K1C) hypertension procedure. Fibrosis and apoptosis were… CONTINUE READING