Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.

@article{Pat2010ChymaseIP,
  title={Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.},
  author={Betty Maki Pat and Yuanwen Chen and Cheryl R. Killingsworth and James D. Gladden and Ke Zhang Shi and Junying Zheng and Pamela Cox Powell and Greg P Walcott and Mustafa I. Ahmed and Himanshu Gupta and Ravi Desai and C C Wei and N. Hase and Tsunefumi Kobayashi and Abdelkarim Sabri and Henk L. M. Granzier and Thomas S. Denney and Michael Tillson and Allen R. Dillon and Ahsan Husain and Louis J. Dell'Italia},
  journal={Circulation},
  year={2010},
  volume={122 15},
  pages={1488-95}
}
BACKGROUND The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinases and kallikrein and degrades fibronectin. Thus, we hypothesize that chymase inhibitor (CI) will attenuate extracellular matrix loss and LV remodeling in MR. METHODS AND RESULTS… CONTINUE READING
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