Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In normal mink, lymph chylomicrons from rats given [3H]retinol (incorporated into retinyl esters, providing a core label) and [14C]oleic acid (incorporated mainly in triglycerides… (More)
Fig. 1. Clearance of TG-labeled chylomicrons in normal mink. Chylomicrons obtained from a donor rat fed [1-14C]oleic acid (incorporated in chylomicron TG) were injected intravenously in fed (left panel) and fasted (right panel) anesthetized mink, same animals as in Tables 1 and 2; s, label in TG and other fatty acid esters; n, label in FFA. Values are percent of injected dose present in the total blood volume (calculated as 7.8% of body weight), mean of five in each group 6 SD.