Chylomicron metabolism in an animal model for hyperlipoproteinemia type I.

@article{Savonen1999ChylomicronMI,
  title={Chylomicron metabolism in an animal model for hyperlipoproteinemia type I.},
  author={Roger Savonen and Knut Nordstoga and Bj\orn O. Christophersen and Anette Lindberg and Yuan Shen and Magnus Hultin and Thomas Olivecrona and Gunilla Olivecrona},
  journal={Journal of lipid research},
  year={1999},
  volume={40 7},
  pages={1336-46}
}
Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of LPL activity but amounts of LPL protein in their tissues similar to those of normal mink. In normal mink, lymph chylomicrons from rats given [3H]retinol (incorporated into retinyl esters, providing a core label) and [14C]oleic acid (incorporated mainly in triglycerides (TG)) were rapidly cleared from the circulation. In the homozygous mink, clearance was much retarded. The ratio of TG to core label in… CONTINUE READING
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Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome

  • J. D. Brunzell
  • 1995

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