ChxR is a transcriptional activator in Chlamydia.

  title={ChxR is a transcriptional activator in Chlamydia.},
  author={Ingrid Chou Koo and Don Walthers and P. Scott Hefty and Linda J Kenney and Richard S. Stephens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 3},
Chlamydia spp. are obligate intracellular bacterial pathogens that alternate between two metabolically and morphologically distinct developmental forms, and differentiation depends on transcriptional regulation. Genome sequencing of Chlamydia trachomatis revealed an ORF, CT630 (chxR), whose amino acid sequence contains a winged helix-turn-helix motif similar to the DNA-binding domain of response regulators in the OmpR subfamily. ChxR differs from many response regulators in that essential… CONTINUE READING