Chunnel vision. Export and efflux through bacterial channel-tunnels.

  title={Chunnel vision. Export and efflux through bacterial channel-tunnels.},
  author={Christian Andersen and Colin Hughes and Vassilis Koronakis},
  journal={EMBO reports},
  volume={1 4},
The Escherichia coli TolC protein is central to toxin export and drug efflux across the inner and outer cell membranes and the intervening periplasmic space. The crystal structure has revealed that TolC assembles into a remarkable alpha-helical trans-periplasmic cylinder (tunnel) embedded in the outer membrane by a contiguous beta-barrel (channel), so providing a large duct open to the outside environment. The channel-tunnel structure is conserved in TolC homologues throughout Gram-negative… CONTINUE READING