Chrysoptin Is a Potent Glycoprotein IIb/IIIa Fibrinogen Receptor Antagonist Present in Salivary Gland Extracts of the Deerfly*

@article{Reddy2000ChrysoptinIA,
  title={Chrysoptin Is a Potent Glycoprotein IIb/IIIa Fibrinogen Receptor Antagonist Present in Salivary Gland Extracts of the Deerfly*},
  author={Vemuri B. Reddy and Kounga Kounga and Fl{\'a}via Corsi Mariano and Ethan A. Lerner},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={15861 - 15867}
}
Salivary gland lysates of the deerfly (genusChrysops) contain chrysoptin, an inhibitor of ADP-induced platelet aggregation, which presumably assists the fly in obtaining a blood meal. Chrysoptin has now been isolated, and its cDNA has been cloned and expressed. Chrysoptin was purified to homogeneity using anion exchange and hydrophobic interaction chromatography and found to be a protein with a molecular mass of 65 kDa as determined by gel electrophoresis. N-terminal amino acid sequencing… 

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