Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro

@inproceedings{Lim2016ChrysophanicAS,
  title={Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro},
  author={Hara Lim and Jinbong Park and Hye-Lin Kim and Jongwook Kang and Mi-Young Jeong and Dong-Hyun Youn and Yunu Jung and Yong-Il Kim and Hyun-Ju Kim and Kwang Seok Ahn and Su-Jin Kim and Seong-Kyu Choe and Seung-Heon Hong and Jae-Young Um},
  booktitle={Front. Pharmacol.},
  year={2016}
}
Chrysophanic acid (CA) is a member of the anthraquinone family abundant in rhubarb, a widely used herb for obesity treatment in Traditional Korean Medicine. Though several studies have indicated numerous features of CA, no study has yet reported the effect of CA on obesity. In this study, we tried to identify the anti-obesity effects of CA. By using 3T3-L1 adipocytes and primary cultured brown adipocytes as in vitro models, high-fat diet (HFD)-induced obese mice, and zebrafish as in vivo models… CONTINUE READING
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