Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

@article{Plaza2010ChrysophaentinsAA,
  title={Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.},
  author={Alberto Plaza and Jessica L. Keffer and Giuseppe Bifulco and John R. Lloyd and Carole A. Bewley},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 26},
  pages={
          9069-77
        }
}
Eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class have been isolated from the marine chrysophyte alga Chrysophaeum taylori. Their structures were determined by extensive 2D NMR and MS techniques and are characterized by the presence of two polyhalogenated, polyoxygenated omega,omega'-diarylbutene units connected by two ether bonds to form the suite of macrocyclic natural products. Chrysophaentin A, the most potent of these antibiotics… Expand
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