Chronotoxicity of methotrexate in mice and its relation to circadian rhythm of DNA synthesis and pharmacokinetics.

@article{Ohdo1997ChronotoxicityOM,
  title={Chronotoxicity of methotrexate in mice and its relation to circadian rhythm of DNA synthesis and pharmacokinetics.},
  author={Shigehiro Ohdo and Kouichi Inoue and Eiji Yukawa and Shun Higuchi and Shigeru Nakano and Nobuya Ogawa},
  journal={Japanese journal of pharmacology},
  year={1997},
  volume={75 3},
  pages={283-90}
}
The mechanisms underlying the circadian rhythm of methotrexate (MTX)-induced toxicity (body weight loss and leukopenia) were investigated from the viewpoints of the sensitivity of living organisms to the drug and the pharmacokinetics of the drug. ICR male mice were housed in a standardized light-dark cycle (lights on at 0700, off at 1900) with food and water ad libitum. The body weight loss after an intraperitoneal injection of MTX (400 mg/kg) was more serious in the late dark period and the… CONTINUE READING

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