Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing.

@article{Hermida2008ChronotherapyWN,
  title={Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing.},
  author={Ram{\'o}n C. Hermida and Diana Elva Ayala and Artemio Moj{\'o}n and Jos{\'e} Ram{\'o}n Fern{\'a}ndez},
  journal={American journal of hypertension},
  year={2008},
  volume={21 8},
  pages={948-54}
}
BACKGROUND Previous studies have shown that the circadian pattern of blood pressure (BP) remains unchanged after either morning or evening dosing of several calcium-channel blockers (CCBs), including amlodipine, isradipine, verapamil, nitrendipine, and cilnidipine. This trial investigated the administration-time dependent antihypertensive efficacy of the slow-release, once-a-day nifedipine gastrointestinal-therapeutic-system (GITS) formulation. METHODS We studied 180 untreated hypertensives… CONTINUE READING
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Reduction of cardiovascular morbidity by increasing the diurnal/nocturnal blood pressure ratio: the MAPEC study

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