Chronotherapy of Trichlormethiazide in Hypertensive Patients

  title={Chronotherapy of Trichlormethiazide in Hypertensive Patients},
  author={A. Fujimura and K. Ohashi and A. Ebihara},
  journal={The Journal of Clinical Pharmacology},
  • A. Fujimura, K. Ohashi, A. Ebihara
  • Published 1991
  • Medicine
  • The Journal of Clinical Pharmacology
  • Circadian influence of trichlormethiazide on serum electrolyte levels, lipid levels, and glucose levels were evaluated in 12 hypertensive patients. One tablet of trichlormethiazide (2 mg) was given once a day at 7:00 am or 7:00 pm for 8 weeks. The study was done by a crossover design. Twenty—four‐hour urine was collected, and fasting blood samples were obtained during the control period and at the end of each treatment period. The 24‐hour urine level increased slightly after treatment with… CONTINUE READING
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    • 82
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    • 62
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    • J. W. Conn
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    • 1965
    • 329