Chronotherapeutics: The Relevance of Timing in Cancer Therapy

  title={Chronotherapeutics: The Relevance of Timing in Cancer Therapy},
  author={Francis L{\'e}vi},
  journal={Cancer Causes & Control},
Cell physiology is regulated along the 24-h time scale by a circadian timing system composed of molecular clocks within each cell and a central coordination system in the brain. The mammalian molecular clock is made of interconnected molecular loops involving at least 12 circadian genes. The cellular clocks are coordinated by the suprachiasmatic nuclei, a hypothalamic pacemaker which also helps the organism adjust to environmental cycles. The rest–activity rhythm is a reliable marker of the… CONTINUE READING
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