Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption.

  title={Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption.},
  author={Shigehiro Ohdo},
  journal={Advanced drug delivery reviews},
  volume={62 9-10},
Mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and influences a multitude of biological processes, including the sleep-wake rhythm. Clock genes are the genes that control the circadian rhythms in physiology and behavior. 24h rhythm is demonstrated for the function of physiology and the pathophysiology of diseases. The effectiveness and toxicity of many drugs vary depending on dosing time. Such chronopharmacological phenomena are influenced by not only the… CONTINUE READING


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