Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.

@article{Huang2008ChronophinMA,
  title={Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.},
  author={Timothy Y. Huang and Laurie S. Minamide and James R. Bamburg and Gary M. Bokoch},
  journal={Developmental cell},
  year={2008},
  volume={15 5},
  pages={691-703}
}
Actin and its key regulatory component, cofilin, are found together in large rod-shaped assemblies in neurons subjected to energy stress. Such inclusions are also enriched in Alzheimer's disease brain, and appear in transgenic models of neurodegeneration. Neuronal insults, such as energy loss and/or oxidative stress, result in rapid dephosphorylation of the cellular cofilin pool prior to its assembly into rod-shaped inclusions. Although these events implicate a role for phosphatases in cofilin… CONTINUE READING
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