Chronopharmacology of mizoribine in collagen-induced arthritis rats.


We previously reported that higher therapeutic effects were obtained in rheumatoid arthritis (RA) patients and RA model animals when the dosing-times of methotrexate and tacrolimus were chosen according to the 24-h rhythms of the inflammatory response. Mizoribine (MZR) is an immunosuppressive agent and is used against RA in the same manner as methotrexate… (More)


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@article{Kanasaki2012ChronopharmacologyOM, title={Chronopharmacology of mizoribine in collagen-induced arthritis rats.}, author={Yuko Kanasaki and Mari Tomonari and Hitoshi Sasaki and Hideto To}, journal={Journal of pharmacological sciences}, year={2012}, volume={120 2}, pages={112-20} }