Chronopharmacology of intrathecal sufentanil for labor analgesia: daily variations in duration of action.

Abstract

BACKGROUND The pharmacokinetic and pharmacodynamic characteristics of opioids vary throughout the day, as demonstrated for oral morphine in chronic pain. However, little is known about the chronobiology of intrathecal lipid soluble opioids used for labor analgesia. The aim of this prospective study was to determine whether the duration of action of… (More)

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@article{Debon2004ChronopharmacologyOI, title={Chronopharmacology of intrathecal sufentanil for labor analgesia: daily variations in duration of action.}, author={Richard Debon and E Boselli and Romain Guyot and Bernard Allaouchiche and Bjorn Lemmer and Dominique Chassard}, journal={Anesthesiology}, year={2004}, volume={101 4}, pages={978-82} }