Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man

  title={Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man},
  author={A. M. Bougerolle and Jean Louis Chabard and Mohammed Jbilou and G{\'e}rard Dordain and Alain Eschalier and Olivier Auma{\^i}tre and Jean Gaillot and J. J. Piron and J. Petit and J. A. Berger},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
SummaryThe bioavailability of two oral formulations of trimipramine, tablets and solution, was performed in twelve healthy volunteers, in a cross-over study. Each formulation was administered in the morning after a fasted period, and in the evening after a meal, in order to evaluate the role of both administration time and food consumption on the plasma kinetic parameters, under usual therapeutic conditions. A high interindividual variability of data was found.First, the extent of… 
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