Chronology of asbestos cancer discoveries: experimental studies of the Saranac Laboratory.

@article{Schepers1995ChronologyOA,
  title={Chronology of asbestos cancer discoveries: experimental studies of the Saranac Laboratory.},
  author={G. W. Schepers},
  journal={American journal of industrial medicine},
  year={1995},
  volume={27 4},
  pages={
          593-606
        }
}
  • G. W. Schepers
  • Published 1995
  • Medicine
  • American journal of industrial medicine
This commentary challenges a recently published perception that Dr. Le Roy Upson Gardner had not actually discovered in 1942 that inhaled chrysotile fibers could induce malignant neoplasia in mice. The handwritten laboratory notes and some of Dr. Gardner's slides have recently been found. They verify that the tumors he saw in the mice included truly malignant neoplasms. Gardner had by then also accumulated 11 cases of human lung cancer (two mesotheliomas) derived from Quebec asbestos miners and… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Pulmonary Asbestosis III: Carcinoma of Lung in Asbesto-Silicosis
Primary carcinoma of the lung has attained a position of major interest in malignant neoplastic disease, through at least a more common recognition, if not more frequent occurrence, within recentExpand
Asbestosis: VI. Analysis of Forty Necropsied Cases
TLDR
In this series of necropsied cases of human asbestosis, there occurs evidence that the disease does not progress beyond a limited time after exposure to asbestos dust ceases, although the fibrosis caused persists and ages into dense scar tissue. Expand
EXPERIMENTAL STUDIES OF ASBESTOSIS
TLDR
Local redema was produced in the animals, with hsemoconcentration, a drop in blood pressure reaching shock level, and a significant reduction in renal function, which is apparently due to circulatory changes, direct action of toxin or both. Expand
Early animal research on asbestos cancer.
  • P. Enterline
  • Medicine
  • American journal of industrial medicine
  • 1993
Lung tumors of primates and rodents.
  • G. Schepers
  • Medicine
  • IMS, Industrial medicine and surgery
  • 1971
An epidemiological study of lung cancer in asbestos miners.
Pulmonary tumors in mice exposed to asbestos dust.
Effect of inhaled commercial hydrous calcium silicate Vorwald AJ , Kark JW ( 1938 ) : Pneumoconiosis and pulmonary carcinoma
  • Am J Pathol
  • 1955
...
1
2
...