Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.

@article{Ohtsuka2012ChronologicalLE,
  title={Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.},
  author={Hokuto Ohtsuka and Kenko Azuma and Sachiko Kubota and Hiroshi Murakami and Yuko Giga-Hama and Hideki Tohda and Hirofumi Aiba},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2012},
  volume={17 1},
  pages={39-52}
}
ecl1+, ecl2+ and ecl3+ genes encode highly homologous small proteins, and their over-expressions confer both H2O2 stress resistance and chronological lifespan extension on Schizosaccharomyces pombe. However, the mechanisms of how these Ecl1 family proteins function have not been elucidated. In this study, we conducted microarray analysis and identified that… CONTINUE READING